成果及论文-Photoacoustic Medical Translation Lab

Photoacoustic Medical Translation Lab

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2026

Photobiomodulation of immune crosstalk rescues neuroinflammation in Alzheimer’s disease models
Qi Shen,Haocai Chang,Junyu Li,Haoyun Guo,Wenbin Shi,Yihua Yan,Wenwen Ouyang,Zhan Zhang,Xiaolei Wu,Da Xing*,Sihua Yang*

Brain, 149(7):awag247,2026
Robust hybrid feature-driven on-the-fly mapping enables freehand 3D panoramic photoacoustic angiography
Haishu Xin, Erqi Wang, Rui Ma, Xin Chen, Yanshen Guo, Xinyue Huang, Fanjia Zeng, Yuanzheng Ma, Kaipeng Zhang, Ting Guo, Zhiyang Wang, Wuyu Zhang, Fei Yang, Yuqin Zhang and Sihua Yang*

Light: Science & Applications,15:328,2026

2025

Optical Attenuation-Resistant Photoacoustic Tomography with Isotropic Contrast via Polarization-Demodulated Magnetic Orientation Awareness
Xiaoye Su, Zhenhui Zhang, Yikai Wang, Dandan Cui, Piao Zhang, Hao Gao, Yuning Liu, Yujiao Shi,* and Sihua Yang*

Laser & Photonics Reviews, e00916, 2025

2024

Parallel diffusion models promote high detail-fidelity photoacoustic microscopy in sparse sampling
Jie Wu, Kaipeng Zhang, Chengeng Huang, Yuanzheng Ma, Rui Ma, Xin Chen, Ting Guo, Sihua Yang, Zhen Yuan, Zhenhui Zhang*

Optics Express, 32, 27574-27590, 2024
Towards in vivo photoacoustic human imaging: Shining a new light on clinical diagnostics
Zhiyang Wang , Fei Yang , Wuyu Zhang, Kedi Xiong, Sihua Yang*

Fundamental Research, 4, 1318-1334, 2024
Advancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy
Fei Yang#, Zhiyang Wang#, Wenbin Shi, Miao Wang, Rui Ma, Wuyu Zhang, Xipeng Li, Erqi Wang, Wenjie Xie, Zhan Zhang, Qi Shen*, Feifan Zhou* & Sihua Yang*

Light: Science & Applications, 13:96,2024
DOVE: Doodled vessel enhancement for photoacoustic angiography super resolution
Yuanzheng Ma, Wangting Zhou, Rui Ma, Erqi Wang, Sihua Yang*, Yansong Tang, Xiao-Ping Zhang, Xun Guan*

Medical Image Analysis，94，103106，2024

2023

Quantitative classification of melasma with photoacoustic microscopy: a pilot study
Zhiyang Wang,Yuying Chen,Shu Pan,Wuyu Zhang,Ziwei Guo,Yuzhi Wang,and Sihua Yang*

Journal of Biomedical Optics，29(S1)：S11504，2023
Ultrafast photoacoustic cavitation pumped by picosecond laser for high-efficient and long-term shockwave theranostics
Dandan Cui, Jie Mi, Zhenhui Zhang, Xiaoye Su, Xiaodong Sun, Gen Mu, Yujiao Shi*, Sihua Yang*

Photoacoustics, 33:e100546, 2023.
Collagen fiber anisotropy characterization by polarized photoacoustic imaging for just-in-time quantitative evaluation of burn severity
Zhenhui Zhang, Wei Chen, Dandan Cui, Jie Mi,Gen Mu, Liming Nie*, Sihua Yang, and Yujiao Shi*

Photonics Research, 11(5):e817-828, 2023.
血管内光声-超声-光学相干层析-光声弹性多模态成像方法及系统
万余洋，雷鹏*，熊科迪，杨思华*

中国激光, 50(3):e0307107, 2023.
Photoacoustic-enabled automatic vascular navigation: accurate and naked-eye real-time visualization of deep-seated vessels
Shu Pan, Li Wang, Yuanzheng Ma, Guangyu Zhang, Rui Liu, Tao Zhang, Kedi Xiong, Siyu Chen, Jian Zhang*, Wende Li*, and Sihua Yang*

Advanced Photonics Nexus, 2(4):e046001, 2023.
Optical-visualized photoacoustic tomographic navigation
Li Wang, Di Ke, Haishu Xin, Rui Liu,Shu Pan, Kedi Xiong, and Sihua Yang*

Applied Physics Letters, 122:e023701, 2023.
Photoacoustic remote sensing elastography
Yanchi Yuan, Xue Wen, Bo Yuan, Haishu Xin, Bingyan Fang, Sihua Yang,and Kedi Xiong*

Optics Letters, 48(9):e2321, 2023.
Photoacoustic/ultrasonic dual-mode imaging for monitoring angiogenesis and synovial erosion in rheumatoid arthritis
Zhen Wang, Zhuangzhuang Tong, Hongjiang Chen, Guangshuai Nie, Jia Hu, Weiyang Liu, Erqi Wang, Bo Yuan, Zhiyang Wang*, Jun Hu*

Photoacoustics, 29:e100458, 2023.
Monitoring the perivascular cerebrospinal fluid dynamics of the glymphatic pathway using co-localized photoacoustic microscopy
Zhiyang Wang, Fei Yang, Wenbin Shi, Wenjie Xie, Zhan Zhang, and Sihua Yang*

Optics Letters, 48(9):e2265, 2023.
Photoacoustic (532 and 1064 nm) and ultrasonic coscanning microscopy for in vivo imaging on small animals: A productized strategy
Wuyu Zhang, Xingzhi Luo, Fei Yang, Zhuangzhuang Tong, Jiaxi Liang, Bo Yuan, Sihua Yang, Zhiyang Wang*

Journal of Biophotonics, e202300007, 2023.
Miniature fiber scanning probe for flexible forward-view photoacoustic endoscopy
Di Ke, Li Wang, Erqi Wang, Haishu Xin, Sihua Yang* and Kedi Xiong*

Applied Physics Letters, 122:e123703, 2023.
High-fluence relay-based disposable photoacoustic-ultrasonic endoscopy for in vivo anatomical imaging of gastrointestinal tract
Xue Wen, Peng Lei, Shengxin Hua, Xiaoyu Chen, Yanchi Yuan, Di Ke, Rui Liu, Jiaxi Liang, Erqi Wang, Bo Wei*, Kedi Xiong*, Sihua Yang*

Photonics Research, 11(1):e55-64, 2023.

2022

Photoacoustic imaging of tumor vascular involvement and surgical margin pathology for feedback-guided intraoperative tumor resection
Zhenhui Zhang, Gen Mu, Erqi Wang, Dandan Cui, Fei Yang, Zhiyang Wang, Sihua Yang, Yujiao Shi*

Applied Physics Letters, 121:e193702, 2022.
Cascade neural approximating for few-shot super-resolution photoacoustic angiography
Yuanzheng Ma, Kedi Xiong, Xuefei Hou, Wuyu Zhang, Xin Chen, Ling Li, Sihua Yang*

Applied Physics Letters, 121:e103701, 2022.
Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β-amyloid load in Alzheimer's disease model
Qi Shen，Xiaolei Wu，Zhan Zhang，Di Zhang, Sihua Yang*，Da Xing*

Aging Cell, 21:e13573, 2022.
Quantitative and Anatomical Imaging of Human Skin by Noninvasive Photoacoustic Dermoscopy
Zhiyang Wang, Fei Yang, Wuyu Zhang, Sihua Yang*

Bio-protocol, 12(07):e4372, 2022.
Bifocal 532/1064 nm alternately illuminated photoacoustic microscopy for capturing deep vascular morphology in human skin
Zhiyang Wang, Fei Yang, Haigang Ma, Zhongwen Cheng, Wuyu Zhang, Kedi Xiong, Tianding Shen, Sihua Yang*

Journal of The European Academy of Dermatology and Venereology, 36:e51, 2022.

2021

Ultrahigh Sensitive and Tumor-Specific Photoacoustography in NIR-II Region: Optical Writing and Redox-Responsive Graphic Fixing by AgBr@PLGA Nanocrystals
Dandan Cui, Yujiao Shi*, Da Xing, Sihua Yang*

Nano Letters, 21(16):e6914, 2021.
Quantitative multilayered assessment of skin lightening by photoacoustic microscopy
Zhiyang Wang, Fei Yang, Zhongwen Cheng, Wuyu Zhang, Kedi Xiong, Tianding Shen, Sihua Yang*

Quantitative Imaging in Medicine and Surgery, 12(1):e1, 2021.
Quantitative and anatomical imaging of dermal angiopathy by noninvasive photoacoustic microscopic biopsy
HaiGang Ma, ZhongWen Cheng, ZhiYang Wang, HaiXia Qiu, TianDing Shen,Da Xing, Ying Gu, Sihua Yang*

Biomedical Optics Express, 12(10):e6300, 2021.
光声显微成像引导注射微整形术研究
张芬，张吴昱，李春澍，童壮壮，马远征，熊科迪*

中国激光, 48(21):e2107002, 2021.
Photoacoustic-guided photothermal therapy by mapping of tumor microvasculature and nanoparticle
Zhiyang Wang, Fei Yang, Zhongwen Cheng, Wuyu Zhang, Kedi Xiong, Sihua Yang*

Nanophotonics, 10(12):e3359, 2021.
Subpixel and On-Line Motion Correction for Photoacoustic Dermoscopy
Zhongwen Cheng , Haigang Ma, Zhiyang Wang, Wuyu Zhang, Fei Yang, Sihua Yang*

IEEE Journal of Selected Toptics in Quantum Electronics, 27(4):e6800408, 2021.
An Ellipsoidal Focused Ultrasound Transducer for Extend-focus Photoacoustic Microscopy
Daocheng Zhang, Zhiyang Wang, Zhongwen Cheng, Wuyu Zhang, Fei Yang, Sihua Yang*

IEEE Transactions on Biomedical Engineering, 2021:e3078729, 2021.
In vivo anatomical imaging of colorectum by tens-of-micron-resolved photoacoustic/ ultrasonic endoscope
Ting Guo, Kedi Xiong*, Zixin Zhang,Ling Li, Sihua Yang

Applied Physics Letters, 118:e153702, 2021.
An excitation-reception collinear probe for ultrasonic, photoacoustic, and thermoacoustic tri-modal volumetric imaging
Zhongwen Cheng, Linghua Wu, Tengsen Qiu, Yihao Duan, Huan Qin*, Jun Hu*, and Sihua Yang*

IEEE Transactions on Medical Imaging, 2021:e3089243, 2021.
Spherical-matching hyperbolic-array photoacoustic computed tomography
Yihao Duan, Zhongwen Cheng, Tengsen Qiu, Liewei Wen, Kedi Xiong*

J. Biophotonics, 2021:e00023, 2021.
High-security photoacoustic identity recognition by capturing hierarchical vascular structure of finger
Mingman Sun, Yuanzheng Ma, Zhuangzhuang Tong, Zhiyang Wang, Wuyu Zhang, Sihua Yang*

J. Biophotonics, 2021:e00086, 2021.
Real-time optical-resolution photoacoustic endoscope
Hui Sun, Wei Wang, Zixin Zhang, Li Wang, Wuyu Zhang, Kedi Xiong*, Sihua Yang

Applied Physics Express, 14:e042012, 2021.
Stereoscopic photoacoustic imaging of radial artery for preoperative evaluation of coronary intervention
Tengsen Qiu, Yihao Duan, Zhongwen Cheng*

Applied Physics Express, 14:e052005, 2021.

2020

Preface to the special issue on “Biomedical Optics”
Dan Zhu*, Walter Blondel, Junle Qu, Xueding Wang, Sihua Yang*

Front Optoelectron, 13(4):e305, 2020.
Spatial weight matrix in dimensionality reduction reconstruction for microelectromechanical system-based photoacoustic microscopy
Yuanzheng Ma, Chang Lu, Kedi Xiong, Wuyu Zhang, Sihua Yang*

Visual Computing for Industry, Biomedicine, and Art, 3(22):e1, 2020.
Reliability assessment on intravascular photoacoustic imaging of lipid: Ex vivo animal and human sample validation
Peng Lei, Jiheng Hao, Lei Wang, Xue Wen, Kedi Xiong, Pengfei Zhang*, Liyong Zhang*, Sihua Yang*

Journal of Biophotonics, 2020(00162):e1, 2020.
Dual Raster-Scanning Photoacoustic Small-Animal Imager for Vascular Visualization
Fei Yang, Zhiyang Wang, Sihua Yang*

Journal of Visualized Experiments, 161:e61584, 2020.
Tomography-assisted Doppler photoacoustic microscopy: proof of concept
Xinkun Wang, Kedi Xiong*, Xin Jin, Sihua Yang

Chinese Optics Letters, 18(10):e101702, 2020.
Photoacoustic and ultrasound (PAUS) dermoscope with high sensitivity and penetration depth by using a bimorph transducer
Zhiyang Wang, Fei Yang, Haigang Ma, Zhongwen Cheng, Sihua Yang*

Journal of Biophotonics, 13:e202000145, 2020.
High-robustness intravascular photoacoustic endoscope with a hermetically sealed opto-sono capsule
Xue Wen, Peng Lei, Kedi Xiong, Pengfei Zhang*, Sihua Yang*

Optics Express, 28(3):e19255, 2020.
In vivo volumetric monitoring of revascularization of traumatized skin using extended depth-of-field photoacoustic microscopy
Zhongwen Cheng, Haigang Ma, Zhiyang Wang, Sihua Yang*

Frontiers of Optoelectronics, 13(4):e307, 2020.
Electrothermal-MEMS-induced nonlinear distortion correction in photoacoustic laparoscopy
Chang Lu, Kedi Xiong*, Yuanzheng Ma, Wuyu Zhang, Zhongwen Cheng, Sihua Yang*

Optics Express, 28(10):e15300, 2020.
High-speed dual-view photoacoustic imaging pen
Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Kedi Xiong, Sihua Yang*

Optics Letters, 45(7):e1599, 2020.
Switchable optical and acoustic resolution photoacoustic dermoscope dedicated into in vivo biopsy-like of human skin
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Wuyu Zhang, Sihua Yang*

Applied Physics Letters, 116:e073703, 2020.
Wide-field monitoring and real-time local recording of microvascular networks on small animals with a dual-raster-scanned photoacoustic microscope
Fei Yang, Zhiyang Wang, Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Ying Gu, Haixia Qiu*, Sihua Yang*

Journal of Biophotonics, 13:e202000022, 2020.

2019

Shape-adapting panoramic photoacoustic endomicroscopy
Kedi Xiong, Wei Wang, Ting Guo, Zhen Yuan, Sihua Yang*

Optics Letters, 44(11):e2681, 2019.
Ultrafine intravascular photoacoustic endoscope with a 0.7 mm diameter probe
Peng Lei, Xue Wen, Lei Wang, Pengfei Zhang* , Sihua Yang*

Optics Letters, 44(22):e5406, 2019.
Imaging of human wrist joint by a flexible-transducerbased morphological-adaptive photoacoustic tomography: a feasibility study
Xin Wang, Sihua Yang*

Chinese Optics Letters, 17(9):e091701, 2019.
Real-time interleaved photoacoustic and ultrasound imaging for guiding interventional procedures
Weicheng Zhang, Jiandong Li, Sihua Yang*

Applied Acoustics, 156:e1, 2019.
High-resolution and extended-depth-of-field photoacoustic endomicroscopy by scanning-domain synthesis of optical beams
Xin Jin, Xinkun Wang, Kedi Xiong*, Sihua Yang*

Optics Express, 27(14):e19369, 2019.
Miniaturized photoacoustic probe for in vivo imaging of subcutaneous microvessels within human skin
Wuyu Zhang, Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Lan Zhang, Sihua Yang*

Quantitative Imaging in Medicine and Surgery, 9(5):e807, 2019.
Large-depth-of-field optical-resolution colorectal photoacoustic endoscope
Xiaowan Li, Kedi Xiong*, Sihua Yang*

Applied Physics Letters, 114:e163703, 2019.
Tapered fiber-based intravascular photoacoustic endoscopy for high-resolution and deep-penetration imaging of lipid-rich plaque
Lei Wang, Peng Lei, Xue Wen, Pengfei Zhang, Sihua Yang*

Optics Express, 27(9):e12832, 2019.
Fast controllable confocal focus photoacoustic microscopy using a synchronous zoom opto-sono objective
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Kedi Xiong, Sihua Yang*

Optics Letters, 44(7):e1880, 2019.
Noncontact photoacoustic angiography with an air-coupled ultrasonic transducer for evaluation of burn injury
Haigang Ma, Kedi Xiong, Junwei Wu, Xuanrong Ji, Sihua Yang*

Applied Physics Letters, 114:e133701, 2019.

2018

Large depth focus-tunable photoacoustic tomography based on clinical ultrasound array transducer
Ruian Liu, Liangzhong Xiang, Da Xing, Jiandong Li, Huan Qin, Weicheng Zhang, Sihua Yang*

Applied Physics Letters, 113:e141102, 2018.
Fast linear confocal scanning photoacoustic dermoscopy for non-invasive assessment of chromatodermatosis
Haigang Ma, Zhongwen Cheng, Zhiyang Wang, Ying Gu, Tingwei Zhang, Haixia Qiu*, Sihua Yang*

Applied Physics Letters, 113:e083704, 2018
Quantitative photoacoustic elasticity and viscosity imaging for cirrhosis detection
Qian Wang, Yujiao Shi*, Fen Yang, and Sihua Yang*

Applied Physics Letters, 112:e211902, 2018
Autofocusing optical-resolution photoacoustic endoscopy
Kedi Xiong, Sihua Yang*, Xiaowan Li, Da Xing

Optics Letters, 43(8):e1846, 2018.
Photoacoustic characteristics of lipid-rich plaques under ultra-low temperature and formaldehyde treatment
Mingjun Xu, Peng Lei, Jianqin Feng, Fangfang Liu, Sihua Yang* , Pengfei Zhang*

Chinese Optics Letters, 16(3):e031702, 2018.
3D depth-coded photoacoustic microscopy with a large field of view for human skin imaging
Zhongwen Cheng, Haigang Ma, Zhiyang Wang, Sihua Yang*

Chinese Optics Letters, 16(8):e081701, 2018.
Label-free photoacoustic imaging guided sclerotherapy for vascular malformations: a feasibility study
Jiawei Sun, Quan Zhou, Sihua Yang*

Optics Express, 26(4):e4967, 2018.
Photoacoustic and hyperspectral dual-modality endoscope
Ning Liu, Sihua Yang*, Da Xing*

Optics Letters, 43(1):e138, 2018.

2017

Thermoacoustic imaging and therapy guidance based on ultra-short pulsed microwave pumped thermoelastic effect induced with superparamagnetic iron oxide nanoparticles
Liewei Wen, Sihua Yang*, Junping Zhong, Quan Zhou, Da Xing*

Theranostics, 7(7):e1976, 2017.
New insight into photoacoustic conversion efficiency by plasmon-mediated nanocaviataion: implications for precision theranostics
Yujiao Shi, Sihua Yang*, Da Xing*

Nano Research, 10(8):e2800, 2017.
Quantifying the plasmonic nanoparticle size effect on photoacoustic conversion efficiency
Yujiao Shi, Sihua Yang*, Da Xing*

Journal of Physical Chemistry C, 121(10):e5805, 2017.
Photoacoustic confocal dermoscope with a waterless coupling and impedance matching opto-sono probe
Haigang Ma, Sihua Yang*, Zhongwen Cheng, Da Xing*

Optics Letters, 42(12):e2342, 2017.
Biomechanical and morphological multi-parameter photoacoustic endoscope for identification of early esophageal disease
Dayang Jin, Fen Yang, Zhongjiang Chen, Sihua Yang*, and Da Xing

Applied Physics Letters, 111:e103703, 2017.
Simultaneous imaging of atherosclerotic plaque composition and structure with dualmode photoacoustic and optical coherence tomography
Shanshan Shang, Zhongjiang Chen, Yue Zhao, Sihua Yang* , Da Xing*

Optics Express, 25(2):e530, 2017.